Interim Estimates of 2025–26 Seasonal Influenza Vaccine Effectiveness — United States, September 2025–February 2026
Weekly / March 12, 2026 / 75(9);116–123
Patrick Maloney, PhD1,2; Emily L. Reeves, MPH1; Kristina Wielgosz, MPH1; Ashley M. Price, MPH1; Karthik Natarajan, PhD3,4; Malini B. DeSilva, MD5; Kristin Dascomb, MD, PhD6; Nicola P. Klein, MD, PhD7; Sara Y. Tartof, PhD8,9; Stephanie A. Irving...
The strongest version of this narrative is that influenza vaccination, even in a season with antigenically drifted viruses, provides measurable protection against illness and hospitalization. The CDC’s data-driven approach, using multiple surveillance networks, reinforces the public health value of vaccination, despite lower-than-ideal effectiveness. The report acknowledges limitations, such as potential confounding factors and sparse data in some strata, which adds credibility to its conclusion...
